abstract：UNLABELLED:In order to create tissue-engineered heart valves with long-term functionality, it is essential to fully understand collagen remodeling during neo-tissue formation. Collagen remodeling is thought to maintain mechanical tissue homeostasis. Yet, the driving factor of collagen remodeling remains unidentified. I...

journal_title：Acta biomaterialia

authors： Oomen PJA,Loerakker S,van Geemen D,Neggers J,Goumans MTH,van den Bogaerdt AJ,Bogers AJJC,Bouten CVC,Baaijens FPT

更新日期：2016-01-01 00:00:00

abstract：UNLABELLED:A novel kind of monodisperse mesoporous manganese silicate coated silica nanoparticle (MMSSN) as a highly efficient T1-weighted MRI contrast agent (CA) and drug carrier for cancer diagnosis and chemotherapy has been constructed by a modified "SiO2 sacrifice and in situ silicate growth" approach under a relat...

journal_title：Acta biomaterialia

authors： Li X,Zhao W,Liu X,Chen K,Zhu S,Shi P,Chen Y,Shi J

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:An underlying abnormality in collagen turnover is implied in the occurrence of complications and recurrences after mesh augmented pelvic floor repair surgeries. Ascorbic acid is a potent stimulant of collagen synthesis. The aim of this study is to produce ascorbic acid releasing poly-lactic acid (PLA) scaffol...

journal_title：Acta biomaterialia

authors： Mangır N,Bullock AJ,Roman S,Osman N,Chapple C,MacNeil S

更新日期：2016-01-01 00:00:00

abstract：UNLABELLED:Despite advances in polymeric nanoparticles (NPs) as effective delivery systems for anticancer drugs, rapid clearance from blood and poor penetration capacity in heterogeneous tumors still remain to be addressed. Here, a dual coating of poly (ethylene glycol)-poly (d,l-lactic acid) (PEG-PDLLA) and water-solu...

journal_title：Acta biomaterialia

authors： Wang G,Chen Y,Wang P,Wang Y,Hong H,Li Y,Qian J,Yuan Y,Yu B,Liu C

更新日期：2016-01-01 00:00:00

abstract：UNLABELLED:The generation of tissue-engineered blood vessel substitutes remains an ongoing challenge for cardiovascular tissue engineering. Full biocompatibility and immediate availability have emerged as central issues for clinical use. To address these issues, we developed a technique that allows the generation of hi...

journal_title：Acta biomaterialia

authors： Aper T,Wilhelmi M,Gebhardt C,Hoeffler K,Benecke N,Hilfiker A,Haverich A

更新日期：2016-01-01 00:00:00

abstract：:The identification of a biologic substrate for maintaining hepatocyte functions is essential to provide reliable and predictable models for in vitro drug screening. In the current study, a three-dimensional culture of hepatocytes was established on highly porous fibrous scaffolds with grafted galactose and RGD to affo...

journal_title：Acta biomaterialia

authors： Yan S,Wei J,Liu Y,Zhang H,Chen J,Li X

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:The regeneration of hyaline cartilage remains clinically challenging. Here, we evaluated the therapeutic effects of using cell-free porous poly(lactic-co-glycolic acid) (PLGA) graft implants (PGIs) along with early loading exercise to repair a full-thickness osteochondral defect. Rabbits were randomly alloca...

journal_title：Acta biomaterialia

authors： Chang NJ,Lin CC,Shie MY,Yeh ML,Li CF,Liang PI,Lee KW,Shen PH,Chu CJ

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:Given the wide spread clinical use of ceramic-based bone void fillers, we sought to determine the efficacy of an FDA-approved β-tricalcium phosphate bone graft substitute (JAX™) in combination with a carboxymethyl cellulose (CMC) handling agent that included a particular heparan glycosaminoglycan (GAG) varia...

journal_title：Acta biomaterialia

authors： Rai B,Chatterjea A,Lim ZXH,Tan TC,Sawyer AA,Hosaka YZ,Murali S,Lee JJL,Fenwick SA,Hui JH,Nurcombe V,Cool SM

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:Recently, we reported on a series of short amphipathic α-helical peptides, comprising the backbone sequence (LLKK)2, with the ability to kill susceptible and drug-resistant Mycobacterium tuberculosis. In this study, the effect of key physicochemical parameters including hydrophobicity and helicity of α-helic...

journal_title：Acta biomaterialia

authors： Khara JS,Lim FK,Wang Y,Ke XY,Voo ZX,Yang YY,Lakshminarayanan R,Ee PLR

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:The use of biomaterials to direct osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of osteogenic supplements is thought to be part of the next generation of orthopedic implants. We previously engineered surface-roughness gradients of average roughness (Ra) varying from the su...

journal_title：Acta biomaterialia

authors： Faia-Torres AB,Charnley M,Goren T,Guimond-Lischer S,Rottmar M,Maniura-Weber K,Spencer ND,Reis RL,Textor M,Neves NM

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:Cardiovascular disease is the leading cause of death in the world. In this study, coaxial electrospinning is employed to fabricate fibers in a core-shell structure with polyvinyl alcohol (PVA) in the core and gelatin in the shell for evaluation as a potential vascular tissue engineering construct. PVA, a syn...

journal_title：Acta biomaterialia

authors： Merkle VM,Tran PL,Hutchinson M,Ammann KR,DeCook K,Wu X,Slepian MJ

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:Here, we demonstrate the possible applications of micropillar arrays in screening anti-metastasis drugs. Human lung adenocarcinoma A549 cells incubated in multiwell plates containing micropillars exhibited markedly different physical/biochemical behavior depending on pillar dimensions. In particular, A549 ce...

journal_title：Acta biomaterialia

authors： Kim J,Choi WJ,Moon SH,Jung J,Park JK,Kim SH,Lee JO

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:Injectable biomaterials have been evaluated as potential new therapies for myocardial infarction (MI) and heart failure. These materials have improved left ventricular (LV) geometry and ejection fraction, yet there remain concerns that biomaterial injection may create a substrate for arrhythmia. Since studie...

journal_title：Acta biomaterialia

authors： Suarez SL,Rane AA,Muñoz A,Wright AT,Zhang SX,Braden RL,Almutairi A,McCulloch AD,Christman KL

更新日期：2015-10-01 00:00:00

abstract：UNLABELLED:Small interfering RNAs (siRNAs) are extensively studied due to their promising potential as therapeutic agents for a wide variety of diseases, including cancer. However, efficient delivery of siRNAs to target cells and tissues is problematic due to a lack of suitable delivery vehicles. In this work, we devel...

journal_title：Acta biomaterialia

authors： Yang Z,Liu T,Xie Y,Sun Z,Liu H,Lin J,Liu C,Mao ZW,Nie S

更新日期：2015-10-01 00:00:00

abstract：UNLABELLED:The irritation/discomfort associated with the use of contact lenses (CLs) is often related to the eyelid-lens friction. Although the use of such devices is widespread, the information about the influence of the lacrimal fluid biomolecules on the tribological behavior of the CLs hydrogels is scarce. In this w...

journal_title：Acta biomaterialia

authors： Silva D,Fernandes AC,Nunes TG,Colaço R,Serro AP

更新日期：2015-10-01 00:00:00

abstract：:A series of six copolymeric families, P(AN-co-MTAs) with various molar fractions of acrylonitrile (fAN) and methacrylates (fMTA) based on 1,3-thiazole and 1,2,3-triazole pendant groups with several spacers of different length and nature (alkyl or succinic), have been synthesized by conventional radical polymerization....

journal_title：Acta biomaterialia

authors： Tejero R,Gutiérrez B,López D,López-Fabal F,Gómez-Garcés JL,Fernández-García M

更新日期：2015-10-01 00:00:00

abstract：UNLABELLED:Antimicrobial peptides (AMPs) are good candidates to treat burn wounds, a major cause of morbidity, impaired life quality and resources consumption in developed countries. We took advantage of a commercially available hydrogel, Carbopol®, a vehicle for topical administration that maintains a moist environmen...

journal_title：Acta biomaterialia

authors： Silva JP,Dhall S,Garcia M,Chan A,Costa C,Gama M,Martins-Green M

更新日期：2015-10-01 00:00:00

abstract：:The wide variety of diatom frustule shapes and intricate architectures provide viable prototypes to guide the design and fabrication of nanodevices and nanostructured materials for applications ranging from sensors to nanotemplates. In this study, a combined experimental-simulation method was developed to probe the po...

journal_title：Acta biomaterialia

authors： Moreno MD,Ma K,Schoenung J,Dávila LP

更新日期：2015-10-01 00:00:00

abstract：:Macrophages represent a large component of the tumour microenvironment and are described to establish interactions with cancer cells, playing crucial roles in several stages of cancer progression. The functional plasticity of macrophages upon stimulation from the environment makes them susceptible to the influence of ...

journal_title：Acta biomaterialia

authors： Cardoso AP,Gonçalves RM,Antunes JC,Pinto ML,Pinto AT,Castro F,Monteiro C,Barbosa MA,Oliveira MJ

更新日期：2015-09-01 00:00:00

abstract：:First-principles calculations were carried out to reveal local atomic arrangements and thermodynamic stability of substitutional divalent cations of Mg(2+), Zn(2+), Sr(2+) and Ba(2+) in tricalcium phosphates (TCPs). There are two modifications of α-TCP and β-TCP, and a number of inequivalent Ca sites are present in th...

journal_title：Acta biomaterialia

authors： Matsunaga K,Kubota T,Toyoura K,Nakamura A

更新日期：2015-09-01 00:00:00

abstract：:Magnesium (Mg) is a promising biomaterial for degradable implant applications that has been extensively studied in vitro and in vivo in recent years. In this study, we developed a procedure that allows an optimized and uniform in vitro assessment of the cytocompatibility of Mg-based materials while respecting the stan...

journal_title：Acta biomaterialia

authors： Jung O,Smeets R,Porchetta D,Kopp A,Ptock C,Müller U,Heiland M,Schwade M,Behr B,Kröger N,Kluwe L,Hanken H,Hartjen P

更新日期：2015-09-01 00:00:00

abstract：UNLABELLED:Many chorioretinal diseases are chronic and need sustained drug delivery systems to keep therapeutic drug level at the disease site. Many intravitreal drug delivery systems under developing do not have mechanism incorporated for a non-invasive monitoring of drug release. The current study prepared rugate por...

journal_title：Acta biomaterialia

authors： Hou H,Nieto A,Belghith A,Nan K,Li Y,Freeman WR,Sailor MJ,Cheng L

更新日期：2015-09-01 00:00:00

abstract：:Small interfering RNA (siRNA) shows great therapeutic potential due to its ability to regulate gene expression in a highly selective manner. However, its application has been limited by ineffective cellular uptake of siRNAs. To achieve successful gene-silencing efficiency, a safe and effective delivery vector is gener...

journal_title：Acta biomaterialia

authors： Pan R,Xu W,Yuan F,Chu D,Ding Y,Chen B,Jafari M,Yuan Y,Chen P

更新日期：2015-07-01 00:00:00

abstract：:Multifunctional bioactive materials with the ability to stimulate osteogenesis and angiogenesis of stem cells play an important role in the regeneration of bone defects. However, how to develop such biomaterials remains a significant challenge. In this study, we prepared mesoporous silica nanospheres (MSNs) with unifo...

journal_title：Acta biomaterialia

authors： Shi M,Zhou Y,Shao J,Chen Z,Song B,Chang J,Wu C,Xiao Y

更新日期：2015-07-01 00:00:00

abstract：:Thin film nitinol has unique mechanical properties (e.g., superelasticity), excellent biocompatibility, and ultra-smooth surface, as well as shape memory behavior. All these features along with its low-profile physical dimension (i.e., a few micrometers thick) make this material an ideal candidate in developing low-pr...

journal_title：Acta biomaterialia

authors： Shayan M,Chun Y

更新日期：2015-07-01 00:00:00

abstract：:For vascular-targeting carrier (VTC) systems to be effective, carriers must be able to localize and adhere to the vascular wall at the target site. Research suggests that neutrally buoyant nanoparticles are limited by their inability to localize to the endothelium, making them sub-optimal as carriers. This study exami...

journal_title：Acta biomaterialia

authors： Thompson AJ,Eniola-Adefeso O

更新日期：2015-07-01 00:00:00

abstract：:A new series of beta Ti-Nb-Zr (TNZ) alloys with considerable plastic deformation ability during compression test, high elastic admissible strain, and excellent cytocompatibility have been developed for removable bone tissue implant applications. TNZ alloys with nominal compositions of Ti-34Nb-25Zr, Ti-30Nb-32Zr, Ti-28...

journal_title：Acta biomaterialia

authors： Ozan S,Lin J,Li Y,Ipek R,Wen C

更新日期：2015-07-01 00:00:00

abstract：:The effects of a biphasic mineralized collagen scaffold (BCS) containing intrafibrillar silica and apatite on osteogenesis of mouse mesenchymal stem cells (mMSCs) and inhibition of receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclastogenesis were investigated in the present study. mMSCs were cult...

journal_title：Acta biomaterialia

authors： Jiao K,Niu LN,Li QH,Chen FM,Zhao W,Li JJ,Chen JH,Cutler CW,Pashley DH,Tay FR

更新日期：2015-06-01 00:00:00

abstract：:Controlling the release of recombinant adeno-associated virus (rAAV) vectors from biocompatible materials is a novel, attractive approach to increase the residence time and effectiveness of a gene carrier at a defined target site. Self-assembling peptides have an ability to form stable hydrogels and encapsulate cells ...

journal_title：Acta biomaterialia

authors： Rey-Rico A,Venkatesan JK,Frisch J,Schmitt G,Monge-Marcet A,Lopez-Chicon P,Mata A,Semino C,Madry H,Cucchiarini M

更新日期：2015-05-01 00:00:00

abstract：:Large three-dimensional poly(glycerol sebacate) (PGS)/poly(l-lactic acid) (PLLA) scaffolds with similar bulk mechanical properties to native low and high stress adapted adipose tissue were fabricated via a freeze-drying and a subsequent curing process. PGS/PLLA scaffolds containing 73vol.% PGS were prepared using two ...

journal_title：Acta biomaterialia

authors： Frydrych M,Román S,MacNeil S,Chen B

更新日期：2015-05-01 00:00:00

abstract：:Critical failures associated with current engineered bone grafts involve insufficient induction of osteogenesis of the implanted cells and lack of vascular integration between graft scaffold and host tissue. This study investigated the combined effects of surface microtextures and biochemical supplements to achieve os...

journal_title：Acta biomaterialia

authors： Song S,Kim EJ,Bahney CS,Miclau T,Marcucio R,Roy S

更新日期：2015-05-01 00:00:00

abstract：:Engineered three-dimensional biomaterials are known to affect the regenerative capacity of stem cells. The extent to which these materials can modify cellular activities is still poorly understood, particularly for adipose-derived stem cells (ASCs). This study evaluates PEGylated fibrin (P-fibrin) gels as an ASC-carry...

journal_title：Acta biomaterialia

authors： Chung E,Rytlewski JA,Merchant AG,Dhada KS,Lewis EW,Suggs LJ

更新日期：2015-04-01 00:00:00

abstract：:Flax seeds produce mucilage after wetting. The mucilage due to its ability to absorb and maintain water is responsible for specific surface properties which are essential for seed dispersal in different ways. In the present paper, we asked how the hydration level affects the adhesive and frictional properties of the m...

journal_title：Acta biomaterialia

authors： Kreitschitz A,Kovalev A,Gorb SN

更新日期：2015-04-01 00:00:00

abstract：:Tissue-derived extracellular matrix (ECM) biomaterials to regenerate the meniscus have gained increasing attention in treating meniscus injuries and diseases, particularly for aged persons and athletes. However, ECM scaffold has poor cell infiltration and can only be implanted using surgical procedures. To overcome th...

journal_title：Acta biomaterialia

authors： Wu J,Ding Q,Dutta A,Wang Y,Huang YH,Weng H,Tang L,Hong Y

更新日期：2015-04-01 00:00:00

abstract：:Engineered tissues are highly limited by poor vascularization in vivo, leading to hypoxia. In order to overcome this challenge, we propose the use of photosynthetic biomaterials to provide oxygen. Since photosynthesis is the original source of oxygen for living organisms, we suggest that this could be a novel approach...

journal_title：Acta biomaterialia

authors： Schenck TL,Hopfner U,Chávez MN,Machens HG,Somlai-Schweiger I,Giunta RE,Bohne AV,Nickelsen J,Allende ML,Egaña JT

更新日期：2015-03-01 00:00:00

abstract：:There is growing interest in the use of synthetic biomaterials to deliver inorganic ions that are known to stimulate angiogenesis and osteogenesis in vivo. In the present study, we investigated the effects of varying amounts of copper in a bioactive glass on the response of human bone marrow-derived mesenchymal stem c...

journal_title：Acta biomaterialia

authors： Zhao S,Wang H,Zhang Y,Huang W,Rahaman MN,Liu Z,Wang D,Zhang C

更新日期：2015-03-01 00:00:00

abstract：:In humans, high level of collagen remodeling is seen during normal physiological events such as bone renewal, as well as in pathological conditions, such as arthritis, tumor growth and other chronic wounds. Our lab recently discovered that collagen mimetic peptide (CMP) is able to hybridize with denatured collagens at...

journal_title：Acta biomaterialia

authors： Chan TR,Stahl PJ,Li Y,Yu SM

更新日期：2015-03-01 00:00:00

abstract：:The present work is an amalgamation of computation and experimental approach to gain an insight into composition-structure-bioactivity relationships of alkali-free bioactive glasses in the CaO-MgO-SiO2-P2O5 system. The glasses have been designed in the diopside (CaO·MgO·2SiO2; Di)-tricalcium phosphate (3CaO·P2O5; TCP)...

journal_title：Acta biomaterialia

authors： Kapoor S,Semitela Â,Goel A,Xiang Y,Du J,Lourenço AH,Sousa DM,Granja PL,Ferreira JM

更新日期：2015-03-01 00:00:00

abstract：:Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) have been shown to generate bone in vivo by executing an endochondral programme. This may hinder the use of MSCs for articular cartilage regeneration, but opens the possibility of using engineered cartilaginous tissues for large bone defect repair. H...

journal_title：Acta biomaterialia

authors： Sheehy EJ,Mesallati T,Vinardell T,Kelly DJ

更新日期：2015-02-01 00:00:00

abstract：:Recapitulation of endochondral ossification leads to a new concept of bone tissue engineering via a cartilage intermediate as an osteoinductive template. In this study, we aimed to investigate the influence of in vitro chondrogenic priming time for the creation of cartilage template on the in vivo endochondral bone fo...

journal_title：Acta biomaterialia

authors： Yang W,Both SK,van Osch GJ,Wang Y,Jansen JA,Yang F

更新日期：2015-02-01 00:00:00